Protein Modification Reagents
Medchemexpress LLC Dnp-peg4-acid | 858126-76-8 | 1 G
DNP-PEG4-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds featuring two ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other targeting a specific protein. These compounds utilize the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- Peg-based PROTAC linker
- Used for the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Facilitates selective degradation of target proteins
- Appearance: viscous liquid
- Color: colorless to light yellow
Chemscene ChemScene | Hydroxy-PEG1-(CH2)2-Boc | 5G | CS-0047718 | 0.96 | 671802-00-9| MFCD22056310 | 190.24
ChemScene | Hydroxy-PEG1-(CH2)2-Boc | 5G | CS-0047718 | 0.96 | 671802-00-9| MFCD22056310 | 190.24
Medchemexpress LLC Propargyl-PEG4-O-C1-Boc | 2098489-63-3 | 97% | 250 MG
Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a versatile click chemistry reagent, featuring an Alkyne group that readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Click chemistry reagent with Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC)
- Molecular formula: C17H30O7
- Molecular weight: 346.42
- For research use only
Medchemexpress LLC Mal-PEG5-NHS ester | 1807537-42-3 | 99.04% | 25 MG
Mal-PEG5-NHS ester is an Alkyl/ether and PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- Alkyl/ether and PEG-based PROTAC linker
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker
Cayman Chemical VH 032 LInker 6 10mg
A PROTAC precursor; has been used in the synthesis of PROTACs targeting Bcl-xL in senescent cells
eMolecules 1343476-41-4 | Acid-PEG5-NHS ester | Broadpharm | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 249969231
Acid-PEG5-NHS ester | Broadpharm | 1343476-41-4 | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 249969231
eMolecules 57436-38-1 | Tos-PEG9-Tos | Broadpharm | MFCD25372005 | 678.810 | C30H46O13S2 | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 229582703
Tos-PEG9-Tos | Broadpharm | 57436-38-1 | MFCD25372005 | 678.810 | C30H46O13S2 | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 229582703
Medchemexpress LLC Tco-peg12-nhs ester | 2185016-39-9 | 96.3% | 866.99 g/mol | C40H70N2O18 | 5 MG
TCO-PEG12-NHS ester is a polyethylene glycol (PEG12) linker containing a trans-cyclooctene (TCO) moiety and an N-hydroxysuccinimide (NHS) ester reactive group. It is used for bioconjugation in research applications, including the synthesis of antibody-drug conjugates (ADCs) and PROTACs, where it provides a cleavable, water-soluble spacer that facilitates targeted payload delivery.
- Provides a PEG12 spacer to increase water solubility and reduce steric hindrance.
- Contains an NHS ester for efficient coupling to primary amines.
- Features a TCO group for rapid, bioorthogonal click chemistry reactions.
- Suitable as a cleavable linker in ADC synthesis and as a linker in PROTAC design.
- Supplied in small research quantities for laboratory synthesis and conjugation workflows.